Issue 16, 2022

Microfabrication of peptide self-assemblies: inspired by nature towards applications

Abstract

Peptide self-assemblies show intriguing and tunable physicochemical properties, and thus have been attracting increasing interest over the last two decades. However, the micro/nano-scale dimensions of the self-assemblies severely restrict their extensive applications. Inspired by nature, to genuinely realize the practical utilization of the bio-organic super-architectures, it is beneficial to further organize the peptide self-assemblies to integrate the properties of the individual supermolecules and fabricate higher-level organizations for smart functional devices. Therefore, cumulative studies have been reported on peptide microfabrication giving rise to diverse properties. This review summarizes the recent development of the microfabrication of peptide self-assemblies, discussing each methodology along with the diverse properties and practical applications of the engineered peptide large-scale, highly-ordered organizations. Finally, the current limitations of the state-of-the-art microfabrication strategies are critically assessed and alternative solutions are suggested.

Graphical abstract: Microfabrication of peptide self-assemblies: inspired by nature towards applications

Article information

Article type
Tutorial Review
Submitted
22 Mar 2022
First published
21 Jul 2022

Chem. Soc. Rev., 2022,51, 6936-6947

Microfabrication of peptide self-assemblies: inspired by nature towards applications

J. Zhang, Y. Wang, B. J. Rodriguez, R. Yang, B. Yu, D. Mei, J. Li, K. Tao and E. Gazit, Chem. Soc. Rev., 2022, 51, 6936 DOI: 10.1039/D2CS00122E

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